Extreme Anticancer Potential of Propolis

Extreme Anticancer Potential of Propolis 4218 136 89 6399 206 32 Google + Posted on: Tuesday, February 4th 2014 at 12:15 pm Written By: Eleni Roumeliotou This article is copyrighted by GreenMedInfo LLC, 2014 Visit our Re-post guidelines Propolis has been used for thousands of years by ancient Egyptians, Greeks and Romans for its multiple medicinal properties and remarkable safety profile, while science only recently started to rediscover its powerful healing potential. Propolis is collected by honeybees from buds and exudates of conifer trees and plants and is known to contain a variety of chemical compounds with significant antioxidant potential, such as flavonoids and phenolic acids. The composition of propolis in the various compounds depends on the geographic area and therefore the different types of plants from which it is collected from. One of the well-studied compounds of propolis is caffeic acid phenethyl ester, abbreviated as CAPE. CAPE has great medicinal properties, but its anti-cancer capacity is of particular interest. A study from the "Journal of Radiation Research" shows that just within 2 days after treatment with CAPE, 46% of lung cancer cells had been destroyed and the cancer growth was reduced by 60%. Three days after the treatment 67% of cancer cells were dead. A similar study published in the journal "Anticancer Drugs" in 2006 found that CAPE prevents colon cancer cells from multiplying and induces programmed cell death of the malignant cells without affecting healthy cells. These impressive results have been replicated in more types of cancer cells, such as breast, gastric, skin and pancreas cancer and glioma cells, a type of inoperable brain cancer. The available data show that CAPE can selectively stop the cell cycle and destroy cancer cells, prevent angiogenesis and block cancer growth. Luckily, it is not just CAPE having this impressive ability. The same anti-cancer properties are even more pronounced and superior in propolis as a whole food. Perhaps the most exciting discovery about the healing effect of propolis and CAPE comes from a recent study published in the journal "Cancer Science and Therapy" in 2014, which shows that treatment with propolis can actually change the expression of DNA. Propolis and CAPE have a dramatic effect on specialized enzymes (called histone deacetylases), which are responsible for regulating the expression of DNA, preventing epigenetic modifications. Epigenetic changes refer to alterations of the DNA expression without changing its sequence, and therefore in the absence of mutations. Modifying enzymes (histone deacetylases) can switch off entire DNA regions and block expression of the genes there. This has been shown to be a powerful way to interrupt normal cellular metabolism and lead to uncontrolled replication, which is certainly involved in cancer growth and metastasis. To prevent these problems, all cells have in their DNA specialized genes, called tumour suppressor genes, which are expected to be activated if a cell becomes cancerous and either promote healing or induce programmed cell death, if the genetic damages are beyond repair. Conveniently, these protective genes are usually deactivated in cancer cells, allowing them to bypass the security mechanisms built in the DNA. This is exactly where propolis acts; by restoring the functions of DNA, it re-activates the ability of the cell to fight off the malignancy and regulate its replication, therefore blocking tumour growth. According to the authors, this study proves that "CAPE and propolis are naturally occurring epigenetic therapeutic agents." The scientific and commercial implications of these findings are so important that an international patent application on this finding was published in January, 2013 by the group, Omene C, O'Connor OA and Frenkel K. This mode of action has been successfully mimicked by pharmaceutical drugs for unresponsive cancers. Histone deacetylase inhibitors are a class of drugs designated as epigenetic agents that modulate the activities of tumour suppressor genes, among others. These drugs were originally used for mood disorders, epilepsy and neurodegenerative diseases. However, since 2006 they have been approved (Vorinostat and Istodax) for specific lymphomas which are unresponsive to other treatments. A study published in the journal "Experimental Hematology" in 2005 reports that these drugs can "profoundly decrease proliferation of human lymphoid cancer cell lines." Just like propolis naturally does with many other types of cancer cells... References Omene C, Kalac M, Wu J, Marchi E, Frenkel K, O'Connor OA. 2014. Propolis and its Active Component, Caffeic Acid Phenethyl Ester (CAPE), Modulate Breast Cancer Therapeutic Targets via an Epigenetically Mediated Mechanism of Action. J Cancer Sci Ther. 5(10):334-342. http://www.ncbi.nlm.nih.gov/pubmed/24466386 Xiang D, Wang D, He Y, Xie J, Zhong Z, Li Z, Xie J. 2006. Caffeic acid phenethyl ester induces growth arrest and apoptosis of colon cancer cells via the beta-catenin/T-cell factor signaling. Anticancer Drugs. 17(7):753-62. http://www.ncbi.nlm.nih.gov/pubmed/16926625 Chen MF, Wu CT, Chen YJ, Keng PC, Chen WC.2004. Cell killing and radiosensitization by caffeic acid phenethyl ester (CAPE) in lung cancer cells. J Radiat Res. 45(2):253-60. http://www.ncbi.nlm.nih.gov/pubmed/15304968 Omene CO, Wu J, Frenkel K. 2012. Caffeic Acid Phenethyl Ester (CAPE) derived from propolis, a honeybee product, inhibits growth of breast cancer stem cells. Invest New Drugs. 30(4):1279-88. http://www.ncbi.nlm.nih.gov/pubmed/21537887 Sakajiri S, Kumagai T, Kawamata N, Saitoh T, Said JW, Koeffler HP. 2005. Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines. Exp Hematol. 33(1):53-61. http://www.ncbi.nlm.nih.gov/pubmed/15661398/ elroum Eleni Roumeliotou is a clinical nutritionist, geneticist and founder of Primal Baby, a health sanctuary for all things pregnancy: before, during and after. Eleni helps women, who are trying to conceive or are already expecting a baby, to optimize their diet and lifestyle in order to conceive naturally and have the healthiest baby possible. Her passion is empowering women to take control of their fertility and their baby´s health, effectively protecting the wellbeing of the next generation, one baby at a time. Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of GreenMedInfo or its staff. Internal Site Commenting is limited to members. Disqus commenting is available to everyone.

U p d a t e ! Healing compounds in propolis

Researchers have identified more than 300 compounds in propolis. The majority of these compounds are forms of polyphenols. Polyphenols are antioxidants that fight disease and damage in the body. Specifically, propolis contains the polyphenols called flavonoids. Flavonoids are produced in plants as a form of protection. They’re commonly found in foods thought to have antioxidant properties, including: fruits green tea vegetables red wine RESEARCH What the research says Propolis is thought to have antibacterial, antiviral, antifungal, and anti-inflammatory properties. But scientific research on propolis is limited. Researchers aren’t exactly sure why, but the bee product appears to provide protection from some bacteria, viruses, and fungi. Wounds Propolis has a special compound called pinocembrin, a flavonoid that acts as an antifungal. These anti-inflammatory and antimicrobial properties make propolis helpful in wound healing. One study found that propolis can help people who have had traumatic burns heal faster by speeding up new healthy cell growth. Another study found that a topical propolis alcoholic extract was more effective than a steroid cream in reducing mast cells in oral surgery wounds. Mast cells are associated with inflammation and slowed wound healing. Cold sores and genital herpes Ointments that contain 3 percent propolis, such as Herstat or Coldsore-FX, may help speed healing time and reduce symptoms in both cold sores and sores from genital herpes. One study found when topical propolis was applied three times a day, it helped to heal cold sores faster than no treatment. The researchers found the propolis cream not only reduced the amount of herpes virus present in a person’s body, but also protected the body against future cold sore breakouts. Cancer Propolis has been suggested to have a role in treating certain cancers as well. According to one study, some of the anti-cancerous effects of the substance include: keeping cancerous cells from multiplying reducing the likelihood cells will become cancerous blocking pathways that keep cancer cells from signaling to each other The study also suggested that propolis could be a complementary therapy — but not a sole treatment — for cancer. Another study found that taking Chinese propolis could be a helpful complementary therapy in treating breast cancer due to its anti-tumor effects on breast cancer cells. SAFETY Safety concerns There is not yet enough evidence to determine whether or not propolis products are safe, but they’re not considered high-risk. People typically take in some propolis when they eat honey. However, if you have an allergy to honey or bees, you will also have a reaction to products containing propolis. Propolis may also cause its own allergic reaction when used for a long time. Beekeepers are some of the people most likely to have a propolis allergy because they’re around the compound so much. The typical allergic reaction is an eczema-like skin breakout. Talk to your doctor before adding propolis to your treatment plan, especially if you have existing allergies or asthma. Currently, there is no medically recommended dose because more research is needed. One study recommends a daily concentration of roughly 70 milligrams per day, but this isn’t an FDA recommendation. Manufacturers may suggest a dose on the product label. Ask your doctor if propolis is safe for you before taking any

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