cytokines any of a number of substances, such as interferon, interleukin, and growth factors, that are secreted by certain cells of the immune system and have an effect on other cells.
Cytokines are cell signalling molecules that aid cell to cell communication in immune responses and stimulate the movement of cells towards sites of inflammation, infection and trauma. Cytokines exist in peptide, protein and glycoprotein (proteins with a sugar attached) forms. cytokines any of a number of substances, such as interferon, interleukin, and growth factors, that are secreted by certain cells of the immune system and have an effect on other cells. Cytokines (cyto, from Greek "κύτταρο" kyttaro "cell" + kines, from Greek "κίνηση" kinisi "movement") are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling. Their release has an effect on the behavior of cells around them. Cytokines are small secreted proteins released by cells have a specific effect on the interactions and communications between cells. Cytokine is a general name ... Cytokines are a large, diverse family of small proteins or glycoproteins (usually smaller than 30 kDa) Cytokines are a large group of proteins, peptides or glycoproteins that are secreted by specific cells of immune system. Cytokines are synthesized in the Golgi and may traffic through the endoplasmic reticulum to be released as soluble mediators, or they may remain membrane ...Cytokines are proteins secreted by cells that interact with specific receptors on other cells, thereby affecting function. Cytokines are a group of proteins made by the immune system that act as chemical messengers. Cytokine: A small protein released by cells that has a specific effect on the interactions between cells, on communications between cells or on the behavior of ... Cytokine: A small protein released by cells that has a specific effect on the interactions between cells, on communications between cells or on the behavior of ... They are released by cells and affect the behavior of other cells, and sometimes the releasing cell itself. There are many types of Cytokines, including chemokines, interferons, interleukins, lymphokines, tumour necrosis factor but generally not hormones or growth factors (despite some terminologic overlap).
Cytokines: Source IL-3: TH, Tc and NK cells
IL-5: TH2 cells, mast cells IL-6: Macrophages, TH2 cells
These videos are designed for medical students https://www.youtube.com/watch?v=YO5Bnb3r70U DIFFERENT TYPES OF CYTOKINES
100lyric
100lyric
Subscribed15,942
Add to Share More
20,044 views
81 8
ShareEmbedEmail
https://youtu.be/YO5Bnb3r70U
Start at:
0:00
Published on Apr 7, 2012
These videos are designed for medical students studying for the USMLE step 1. Feel free to comment and suggest what you would like to see in the future, and I will do my best to fulfill those requests.
Category
Education
License
Standard YouTube License
SHOW LESS
COMMENTS • 10
Oscar del Rosario
Add a public comment...
Top comments
david alj
david alj4 months ago
Which cytokine(s) is/are responsible for its/theirs antiviral activities? (1p)
A. IL‐2
B. IFN‐
C. IL‐4
D. IFN‐
E. TNF‐
F. IL‐1
Read more
Reply
JesusLovesYou
JesusLovesYou3 years ago
do u mean IgM to IgE and IgG? ... thanks again this is awesome
Reply
Aswani Kumar
Aswani Kumar3 years ago
very nice. thanx a lott doc
Reply
katkittykiwi
katkittykiwi3 years ago
what does that even mean?
Reply
Sirtuin 607
Sirtuin 6073 years ago
for IFN-y, what about mentioning TNF-a
Reply
100lyric
100lyric4 years ago
My pleasure....glad you liked it.
Reply
medicalhockey
medicalhockey4 years ago
Thanks for the quick example. Well done
Reply
majicninja21
majicninja214 years ago
you shit the bed on this one
Reply
100lyric
100lyric4 years ago
Thank you .....glad you liked it...
Reply
Shilpa UM
Shilpa UM4 years ago
Nicely done.quick review of cytokines. thanks
Reply
Autoplay
Up next
Cytokines and cytokine receptors
Shomu's Biology
68,259 views
15:01
Cytokines (HD)
Rabiul Haque
29,857 views
35:15
Interleukins & Cytokines (Immunology) || USMLE
DirtyUSMLE
18,218 views
6:28
Interleukin Mnemonic Memory Tool
Med School Made Easy
11,261 views
3:49
The Science of Inflammation Part 3 - Cytokines
dreamarketing
24,229 views
10:04
Cytokines - IL-2, IL-3, Interferon-gamma, IL-4, IL-5, IL-10 - Secreted by T Cells
USMLEFastTrack
10,645 views
3:10
Immunology cytokines
thomas underhill
4,142 views
9:42
10 Ways To Make Money Online Selling Your Photos
Justin Bryant
Recommended for you
19:22
Review of B cells, CD4+ T cells and CD8+ T cells | NCLEX-RN | Khan Academy
Khan Academy
656,770 views
11:07
83P - Transplant rejection - Immunological basis and explanation, MHC, CD4+, CD8+, T cell
Kevin Mangum
49,197 views
16:14
Cytokines - IL-1, IL-6,IL-8, IL-12 & TNF-alpha - Secreted by macrophages
USMLEFastTrack
42,756 views
2:43
How To Get Rid Of Mice Permanently In All Natural Way!
Sigaga Namy
Recommended for you
4:01
Urgent Message To All Catholics Around The World! A Must See Video!!! - 2017
elnieto007
Recommended for you
8:50
B & T Cell Activation & Development, Cytokines, MHC 1 CD40 TNF B7 IL 2 LTB4 CD4 CD8
Stomp On Step 1
21,778 views
20:59
Overview of the Immune System
Handwritten Tutorials
415,530 views
5:56
How Hormones Use G-protein Signaling Pathways: A Video Review of the Basics.
UofLPhysio
121,286 views
9:50
Cytokines network & their receptors (IMMUNOLOGY 6) part-1
MED13
1,796 views
46:17
Physiology of Inflammation
Andrew Wolf
http://encodeicf.blogspot.com/2017/02/we-have-also-identified-that-some.html Stomach and mood disorders: how your gut may be playing with your mind
February 24, 2016 6.05am AEDT
For years, we’ve known that brain activity can affect our gut. amanda tipton/Flickr, CC BY
Author
Nicholas Talley
Deputy Vice-Chancellor Research (Acting) and Pro Vice-Chancellor, Faculty of Health and Medicine, University of Newcastle
Disclosure statement
Nicholas Talley receives funding from University of Newcastle and NHMRC Grants.
Partners
University of Newcastle
University of Newcastle provides funding as a member of The Conversation AU.
View all partners
Republish this article
Republish Republish our articles for free, online or in print, under Creative Commons licence.
Email
Twitter209
Facebook6k
LinkedIn116
Print
If you’ve eaten a fabulous meal recently, the experience was pleasant, comfortable and pain-free because your stomach and intestinal system worked seamlessly to move the food along and eventually absorb it.
Our gastrointestinal tract, or gut, is sometimes described as our “second brain”. This is because it is controlled by its own complex nervous system comprising hundreds of millions of neurons – more than all the nerves in your spinal cord.
The gut and brain talk to each other through nerve signals, the release of gut or stress hormones, and other pathways. We have long known that emotions can directly alter gut function.
But lately we’ve been discovering that it works the other way too: our gut actually has an effect on our brain. And because it’s easier (and generally safer) to manipulate the gut than the brain, this knowledge provides the possibility that doing so could treat some chronic psychological and brain diseases.
How your brain affects you gut
Think of a time you had to do an exam and had “the runs” (diarrhoea) or felt anxious and developed butterflies in your stomach. This is your brain driving your gut. If you are stressed or anxious, you even change the production of stomach acid through nerve connections.
Think of a time you had to do an exam and had the runs. from shutterstock.com
Traditionally it was thought gut symptoms came about from an underlying psychological disorder, such as anxiety. Anxiety changes gut function. Over time, this can lead to unpleasant symptoms such as pain, diarrhoea, bloating or excessive fullness.
Many people who suffer from irritable bowel syndrome (IBS) or severe indigestion are anxious, for instance. And doctors have investigated antidepressants and psychological treatments in these disorders with variable success.
But actually many signals go up to the brain from the gut as well as in the downward direction. So could it be that in some cases, changes in the gut are actually driving anxiety experiences rather than the other way around? Accumulating evidence suggests this is likely to be the case.
How the gut changes your brain
We followed 1,002 people over a 12-year period in Sydney and found about 50% of the participants with chronic gut issues had been anxious first and then developed their gut problems.
But the other 50% developed the gut disorder before the psychological problems arose. In other words, their gut appeared to get sick first and this led to brain dysfunction manifesting as anxiety, not the other way around.
We later observed similar findings – that psychological distress can predict later onset of gut disorders and vice versa – in a large study in the United Kingdom.
We know that some people with IBS have mild gut inflammation. We have also identified that some people with IBS have elevated levels of cytokines in their blood. These are byproducts of inflammation; part of the immune response.
One study showed a clear increase of certain cytokines in people with both anxiety and IBS. Higher anxiety levels strongly correlated with higher cytokine levels. Based on this new information, we concluded that gut inflammation releases cytokines that may cause anxiety in IBS.
How the bugs in your gut alter your brain
Everyone’s gut is chock a block full of bugs (trillions of them) that can be good, bad or indifferent. They hang out all the way from the mouth through to the end of the bowel.
Everyone’s gut is chock a block full of bugs. from shutterstock.com
The bugs talk to the nervous system through pathways, including the immune system, that keeps them in check. Experimental work suggests an imbalance in these bugs can affect the brain and, in some cases, may lead to anxiety or depression.
Altering gut bacteria is a new way to treat many diseases of the gut and possibly the brain, including through diets (changing your diet rapidly changes your gut bugs), or by providing “good” bacteria and suppressing “bad” bacteria, that can be done with probiotics. Other methods include transplanting stool from healthy people to those in need.
Intriguing observations could also unlock new ways to manage currently incurable degenerative nervous diseases. For instance, altered gut function manifesting as constipation is often the first symptom of Parkinson’s disease.
And studies are currently exploring the role of the gut in neurological diseases such as multiple sclerosis.
But for the moment, new evidence suggests when the gut is inflamed, it may affect the brain and lead to psychological dysfunction.
Anxiety
Microbiome
gut
Gastroenterology
gastrointestinal tract
Mood disorders
Irritable Bowel Syndrome
http://encodeicf.blogspot.com/2017/02/we-have-also-identified-that-some.html http://aglobalhealthwarrior.blogspot.com/2017/02/cytokines-any-of-number-of-substances.html
No comments:
Post a Comment